Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer.

ABSTRACT: The p53 protein is critical for multiple cellular functions including cell growth and DNA repair. We assessed whether polymorphisms in the region encoding TP53 were associated with risk of invasive ovarian cancer. The study population includes a total of 5,206 invasive ovarian cancer cases (2,829 of which were serous) and 8,790 controls from 13 case-control or nested case-control studies participating in the Ovarian Cancer Association Consortium (OCAC). Three of the studies performed independent discovery investigations involving genotyping of up to 23 single nucleotide polymorphisms (SNP) in the TP53 region. Significant findings from this discovery phase were followed up for replication in the other OCAC studies. Mixed effects logistic regression was used to generate posterior median per

SUBMITTER: Schildkraut JM 

PROVIDER: S-EPMC2666150 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature