Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.

ABSTRACT: Plasma lipoprotein(a) (Lp[a]) level is an independent risk factor of cardiovascular disease that is under strong genetic control. We conducted a genome-wide association study of plasma Lp(a) in 386 members of a founder population that adheres to a communal lifestyle, proscribes cigarette smoking, and prepares and eats meals communally. We identified associations with 77 single nucleotide polymorphisms (SNPs) spanning 12.5 Mb on chromosome 6q26-q27 that met criteria for genome-wide significance (P

SUBMITTER: Ober C 

PROVIDER: S-EPMC2666166 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature