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Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.

ABSTRACT: Plasma lipoprotein(a) (Lp[a]) level is an independent risk factor of cardiovascular disease that is under strong genetic control. We conducted a genome-wide association study of plasma Lp(a) in 386 members of a founder population that adheres to a communal lifestyle, proscribes cigarette smoking, and prepares and eats meals communally. We identified associations with 77 single nucleotide polymorphisms (SNPs) spanning 12.5 Mb on chromosome 6q26-q27 that met criteria for genome-wide significance (P

SUBMITTER: Ober C

PROVIDER: S-EPMC2666166 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.

Ober Carole C Nord Alex S AS Thompson Emma E EE Pan Lin L Tan Zheng Z Cusanovich Darren D Sun Ying Y Nicolae Raluca R Edelstein Celina C Schneider Daniel H DH Billstrand Christine C Pfaffinger Ditta D Phillips Natasha N Anderson Rebecca L RL Philips Binu B Rajagopalan Ramakrishnan R Hatsukami Thomas S TS Rieder Mark J MJ Heagerty Patrick J PJ Nickerson Deborah A DA Abney Mark M Marcovina Santica S Jarvik Gail P GP Scanu Angelo M AM Nicolae Dan L DL

Journal of lipid research 20090105 5

Plasma lipoprotein(a) (Lp[a]) level is an independent risk factor of cardiovascular disease that is under strong genetic control. We conducted a genome-wide association study of plasma Lp(a) in 386 members of a founder population that adheres to a communal lifestyle, proscribes cigarette smoking, and prepares and eats meals communally. We identified associations with 77 single nucleotide polymorphisms (SNPs) spanning 12.5 Mb on chromosome 6q26-q27 that met criteria for genome-wide significance ( ...[more]

PMID: 19124843

Dataset Information

Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.

Publications

Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.

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