Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis.

ABSTRACT:

Background and objectives

Extended hemodialysis using a high cut-off dialyzer (HCO-HD) removes large quantities of free light chains in patients with multiple myeloma. However, the clinical utility of this method is uncertain. This study assessed the combination of chemotherapy and HCO-HD on serum free light chain concentrations and renal recovery in patients with myeloma kidney (cast nephropathy) and dialysis-dependent acute renal failure.

Design, setting, participants, & measurements

An open-label study of the relationship between free light chain levels and clinical outcomes in 19 patients treated with standard chemotherapy regimens and HCO-HD.

Results

There were sustained early reductions in serum free light chain concentrations (median 85% [range 50 to 97]) in 13

SUBMITTER: Hutchison CA 

PROVIDER: S-EPMC2666427 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature