Effects of cardiopulmonary bypass on propofol pharmacokinetics and bispectral index during coronary surgery.

ABSTRACT:

Purpose

Cardiopulmonary bypass is known to alter propofol pharmacokinetics in patients undergoing cardiac surgery. However, few studies have evaluated the impact of these alterations on postoperative pharmacodynamics. This study was designed to test the hypothesis that changes in propofol pharmacokinetics increase hypnotic effects after cardiopulmonary bypass.

Methods

Twenty patients scheduled for on-pump coronary artery bypass graft (group, n=10) or off-pump coronary artery bypass graft (group, n=10) coronary artery bypass grafts were anesthetized with sufentanil and a propofol target controlled infusion (2.0 microg/mL). Depth of hypnosis was monitored using the bispectral index. Blood samples were collected from the induction of anesthesia up to 12 hours after the end of p

SUBMITTER: Barbosa RA 

PROVIDER: S-EPMC2666455 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature