FTO gene variation and measures of body mass in an African population.

ABSTRACT:

Background

Variation in the fat mass and obesity associated (FTO) gene has been reproducibly associated with body mass index (BMI) and obesity in populations of White European origin. Data from Asians and African-Americans is less conclusive.

Methods

We assessed the effect of 16 FTO polymorphisms on body mass in a large population of predominantly lean Gambians (N(max) 2208) participating in a long-term surveillance program providing contemporary and early-life anthropometric measurements.

Results

Sixteen FTO tagSNPs screened here, including several associated with BMI in Europeans, were not associated with birth weight (BWT), early weight gain in 1-2 year olds, BMI in adults (> or = 18 y), or weight-for-height (WFH) z-score across all ages. No association was seen be

SUBMITTER: Hennig BJ 

PROVIDER: S-EPMC2666669 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature