RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.

ABSTRACT:

Background

Generalized anxiety disorder (GAD) is a common and sometimes disabling condition often associated with stressful life events that involve significant loss or danger. The disorder appears moderately heritable. Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were recently associated with anxious behavior in mice and panic disorder and trait anxiety in humans. We examined whether rs4606, a single nucleotide polymorphism (SNP) in the 3' UTR of RGS2, was associated with GAD in an epidemiologic sample of adults exposed to the 2004 Florida Hurricanes.

Methods

The sample for the current study is 607 adults from the 2004 Florida Hurricane Study who returned buccal DNA samples via mail. Participants were selected via random digit dial procedures and inte

SUBMITTER: Koenen KC 

PROVIDER: S-EPMC2666784 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature