Predicting helix-helix interactions from residue contacts in membrane proteins.

ABSTRACT:

Motivation

Helix-helix interactions play a critical role in the structure assembly, stability and function of membrane proteins. On the molecular level, the interactions are mediated by one or more residue contacts. Although previous studies focused on helix-packing patterns and sequence motifs, few of them developed methods specifically for contact prediction.

Results

We present a new hierarchical framework for contact prediction, with an application in membrane proteins. The hierarchical scheme consists of two levels: in the first level, contact residues are predicted from the sequence and their pairing relationships are further predicted in the second level. Statistical analyses on contact propensities are combined with other sequence and structural information for traini

SUBMITTER: Lo A 

PROVIDER: S-EPMC2666818 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature