Endometrium as an early sensor of in vitro embryo manipulation technologies.

ABSTRACT: Implantation is crucial for placental development that will subsequently impact fetal growth and pregnancy success with consequences on postnatal health. We postulated that the pattern of genes expressed by the endometrium when the embryo becomes attached to the mother uterus could account for the final outcome of a pregnancy. As a model, we used the bovine species where the embryo becomes progressively and permanently attached to the endometrium from day 20 of gestation onwards. At that stage, we compared the endometrial genes profiles in the presence of an in vivo fertilized embryo (AI) with the endometrial patterns obtained in the presence of nuclear transfer (SCNT) or in vitro fertilized embryos (IVF), both displaying lower and different potentials for term development. Our data provid

SUBMITTER: Mansouri-Attia N 

PROVIDER: S-EPMC2667091 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature