Snapshot of iron response in Shewanella oneidensis by gene network reconstruction.

ABSTRACT:

Background

Iron homeostasis of Shewanella oneidensis, a gamma-proteobacterium possessing high iron content, is regulated by a global transcription factor Fur. However, knowledge is incomplete about other biological pathways that respond to changes in iron concentration, as well as details of the responses. In this work, we integrate physiological, transcriptomics and genetic approaches to delineate the iron response of S. oneidensis.

Results

We show that the iron response in S. oneidensis is a rapid process. Temporal gene expression profiles were examined for iron depletion and repletion, and a gene co-expression network was reconstructed. Modules of iron acquisition systems, anaerobic energy metabolism and protein degradation were the most noteworthy in the gene network. Bi

SUBMITTER: Yang Y 

PROVIDER: S-EPMC2667191 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature