Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways.

ABSTRACT:

Background

Calorie restriction (CR) is the only intervention known to extend lifespan in a wide range of organisms, including mammals. However, the mechanisms by which it regulates mammalian aging remain largely unknown, and the involvement of the TOR and sirtuin pathways (which regulate aging in simpler organisms) remain controversial. Additionally, females of most mammals appear to live longer than males within species; and, although it remains unclear whether this holds true for mice, the relationship between sex-biased and CR-induced gene expression remains largely unexplored.

Methodology/principal findings

We generated microarray gene expression data from livers of male mice fed high calorie or CR diets, and we find that CR significantly changes the expression of over 3

SUBMITTER: Estep PW 

PROVIDER: S-EPMC2667255 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature