Mining the ovarian cancer ascites proteome for potential ovarian cancer biomarkers.

ABSTRACT: Current ovarian cancer biomarkers are inadequate because of their relatively low diagnostic sensitivity and specificity. There is a need to discover and validate novel ovarian cancer biomarkers that are suitable for early diagnosis, monitoring, and prediction of therapeutic response. We performed an in-depth proteomics analysis of ovarian cancer ascites fluid. Size exclusion chromatography and ultrafiltration were used to remove high abundance proteins with molecular mass >/=30 kDa. After trypsin digestion, the subproteome (

SUBMITTER: Kuk C 

PROVIDER: S-EPMC2667349 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature