Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart.

ABSTRACT:

Background

The heart is capable of maintaining contractile function despite a transient decrease in blood flow and increase in cardiac ATP demand during systole. This study analyzes a previously developed model of cardiac energetics and oxygen transport to understand the roles of the creatine kinase system and myoglobin in maintaining the ATP hydrolysis potential during beat-to-beat transient changes in blood flow and ATP hydrolysis rate.

Results

The theoretical investigation demonstrates that elimination of myoglobin only slightly increases the predicted range of oscillation of cardiac oxygenation level during beat-to-beat transients in blood flow and ATP utilization. In silico elimination of myoglobin has almost no impact on the cytoplasmic ATP hydrolysis potential (DeltaG

SUBMITTER: Wu F 

PROVIDER: S-EPMC2667476 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature