Morning ghrelin concentrations are not affected by short-term overfeeding and do not predict ad libitum food intake in humans.

ABSTRACT:

Background

Ghrelin has a short-term orexigenic effect but may also be a marker of food intake over time. We previously found an inverse association between ghrelin concentrations and food intake.

Objectives

The objectives were to determine whether the fasting plasma ghrelin concentration is related to food intake and whether the previous day's intake predicts the suppression of ghrelin.

Design

Sixty-nine nondiabetic adults (40 men) aged 33 +/- 9 y were studied as inpatients at a Clinical Research Center. After 6 d of consuming a maintenance diet, the subjects self-selected their food from our vending machine system for 3 d. Total plasma ghrelin concentrations were measured every morning during the vending machine period.

Results

The fasting ghrelin concentratio

SUBMITTER: Votruba SB 

PROVIDER: S-EPMC2667652 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature