Noradrenergic depression of neuronal excitability in the entorhinal cortex via activation of TREK-2 K+ channels.

ABSTRACT: The entorhinal cortex is closely associated with the consolidation and recall of memories, Alzheimer disease, schizophrenia, and temporal lobe epilepsy. Norepinephrine is a neurotransmitter that plays a significant role in these physiological functions and neurological diseases. Whereas the entorhinal cortex receives profuse noradrenergic innervations from the locus coeruleus of the pons and expresses high densities of adrenergic receptors, the function of norepinephrine in the entorhinal cortex is still elusive. Accordingly, we examined the effects of norepinephrine on neuronal excitability in the entorhinal cortex and explored the underlying cellular and molecular mechanisms. Application of norepinephrine-generated hyperpolarization and decreased the excitability of the neurons in the su

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC2667783 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature