Altered global gene expression in first trimester placentas of women destined to develop preeclampsia.

ABSTRACT:

Background

Preeclampsia is a pregnancy-specific disorder that remains a leading cause of maternal, fetal and neonatal morbidity and mortality, and is associated with risk for future cardiovascular disease. There are no reliable predictors, specific preventative measures or treatments other than delivery. A widely held view is that the antecedents of preeclampsia lie with impaired placentation in early pregnancy. Accordingly, we hypothesized dysregulation of global gene expression in first trimester placentas of women who later manifested preeclampsia.

Methods

Surplus chorionic villus sampling (CVS) tissues were collected at 10-12 weeks gestation in 160 patients with singleton fetuses. Four patients developed preeclampsia, and their banked CVS specimens were matched to 8 cont

SUBMITTER: Founds SA 

PROVIDER: S-EPMC2667803 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature