Searching for genotype-phenotype structure: using hierarchical log-linear models in Crohn disease.

ABSTRACT: There has been considerable recent success in the detection of gene-disease associations. We consider here the development of tools that facilitate the more detailed characterization of the effect of a genetic variant on disease. We replace the simplistic classification of individuals according to a single binary disease indicator with classification according to a number of subphenotypes. This more accurately reflects the underlying biological complexity of the disease process, but it poses additional analytical difficulties. Notably, the subphenotypes that make up a particular disease are typically highly associated, and it becomes difficult to distinguish which genes might be causing which subphenotypes. Such problems arise in many complex diseases. Here, we concentrate on an applicatio

SUBMITTER: Chapman JM 

PROVIDER: S-EPMC2668013 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature