SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila.

ABSTRACT: Legionella pneumophila is the causative agent of the severe and potentially fatal pneumonia Legionnaires' disease. L. pneumophila is able to replicate within macrophages and protozoa by establishing a replicative compartment in a process that requires the Icm/Dot type IVB secretion system. The signals and regulatory pathways required for Legionella infection and intracellular replication are poorly understood. Mutation of the rpoS gene, which encodes sigma(S), does not affect growth in rich medium but severely decreases L. pneumophila intracellular multiplication within protozoan hosts. To gain insight into the intracellular multiplication defect of an rpoS mutant, we examined its pattern of gene expression during exponential and postexponential growth. We found that sigma(S) affects disti

SUBMITTER: Hovel-Miner G 

PROVIDER: S-EPMC2668410 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature