Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins.

ABSTRACT: Cell division in bacteria requires the coordinated action of a set of proteins, the divisome, for proper constriction of the cell envelope. Multiple protein-protein interactions are required for assembly of a stable divisome. Within the Escherichia coli divisome is a conserved subcomplex of inner membrane proteins, the FtsB/FtsL/FtsQ complex, which is necessary for linking the upstream division proteins, which are predominantly cytoplasmic, with the downstream division proteins, which are predominantly periplasmic. FtsB and FtsL are small bitopic membrane proteins with predicted coiled-coil motifs, which themselves form a stable subcomplex that can recruit downstream division proteins independently of FtsQ; however, the details of how FtsB and FtsL interact together and with other proteins

SUBMITTER: Gonzalez MD 

PROVIDER: S-EPMC2668415 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature