Artificial enzymes with thiazolium and imidazolium coenzyme mimics.

ABSTRACT: Hydrophobic thiazolium and imidazolium coenzyme mimics in the presence of modified-polyethylenimine enzyme mimics catalyze the benzoin condensation 2300-3300 times faster than the coenzyme mimics alone. Polycationic enzyme mimics provide not only a hydrophobic binding domain for coenzyme and substrate, but also electrostatic stabilization of anionic species that arise along the reaction pathway of the benzoin condensation.

SUBMITTER: Zhao H 

PROVIDER: S-EPMC2668524 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature