Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway.

ABSTRACT:

Background

Cellular oxidative stress is an important factor in asthma and is thought to be the principle mechanism by which oxidant pollutants such as ozone and particulates mediate their pro-inflammatory effects. Endogenous Phase II enzymes abrogate oxidative stress through the scavenging of reactive oxygen species and metabolism of reactive chemicals.

Objective

We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.

Methods

Study subjects consumed oral sulforapha

SUBMITTER: Riedl MA 

PROVIDER: S-EPMC2668525 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature