Buffering of segmental and chromosomal aneuploidies in Drosophila melanogaster.

ABSTRACT: Chromosomal instability, which involves the deletion and duplication of chromosomes or chromosome parts, is a common feature of cancers, and deficiency screens are commonly used to detect genes involved in various biological pathways. However, despite their importance, the effects of deficiencies, duplications, and chromosome losses on the regulation of whole chromosomes and large chromosome domains are largely unknown. Therefore, to explore these effects, we examined expression patterns of genes in several Drosophila deficiency hemizygotes and a duplication hemizygote using microarrays. The results indicate that genes expressed in deficiency hemizygotes are significantly buffered, and that the buffering effect is general rather than being mainly mediated by feedback regulation of individu

SUBMITTER: Stenberg P 

PROVIDER: S-EPMC2668767 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature