Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury.

ABSTRACT:

Rationale

Although reactive oxygen species (ROS) are generally considered to be proinflammatory and to contribute to cellular and organ dysfunction when present in excessive amounts, there is evidence that specific ROS, particularly hydrogen peroxide (H(2)O(2)), may have antiinflammatory properties.

Objectives

To address the role that increases in intracellular H(2)O(2) may play in acute inflammatory processes, we examined the effects of catalase inhibition or the absence of catalase on LPS-induced inflammatory responses.

Methods

Neutrophils from control or acatalasemic mice, or control neutrophils incubated with the catalase inhibitor aminotriazole, were treated with LPS, and levels of reactive oxygen species, proteasomal activity, NF-kappaB activation, and proinflam

SUBMITTER: Zmijewski JW 

PROVIDER: S-EPMC2668804 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature