Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes.

ABSTRACT:

Aims/hypothesis

The sterol regulatory element-binding factor (SREBF)-1c is a transcription factor involved in the regulation of lipid and glucose metabolism. We have previously found evidence that a common SREBF1c single-nucleotide polymorphism (SNP), located between exons 18c and 19c, is associated with an increased risk of type 2 diabetes. The present study aimed to replicate our previously reported association in a larger case-control study and to examine an additional five SREBF1c SNPs for their association with diabetes risk and plasma glucose concentrations.

Methods

We genotyped six SREBF1c SNPs in two case-control studies (n=1,938) and in a large cohort study (n=1,721) and tested for association with type 2 diabetes and with plasma glucose concentrations (fasting and

SUBMITTER: Harding AH 

PROVIDER: S-EPMC2668914 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature