Analysis of colorectal adenoma recurrence data subject to informative censoring.

ABSTRACT: The treatment effect of a colorectal polyp prevention trial is often evaluated from the colorectal adenoma recurrence status at the end of the trial. However, early colonoscopy from some participants complicates estimation of the final study end recurrence rate. The early colonoscopy could be informative of status of recurrence and induce informative differential follow-up into the data. In this article, we use midpoint imputation to handle interval-censored observations. We then apply a weighted Kaplan-Meier method to the imputed data to adjust for potential informative differential follow-up, while estimating the recurrence rate at the end of the trial. In addition, we modify the weighted Kaplan-Meier method to handle a situation with multiple prognostic covariates by deriving a risk sco

SUBMITTER: Hsu CH 

PROVIDER: S-EPMC2668929 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature