Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation.

ABSTRACT:

Background

Brain-derived neurotrophic factor (BDNF) is believed to be an important regulator of striatal neuron survival, differentiation, and plasticity. Moreover, reduction of BDNF delivery to the striatum has been implicated in the pathophysiology of Huntington's disease. Nevertheless, many essential aspects of BDNF responses in striatal neurons remain to be elucidated.

Methodology/principal findings

In this study, we assessed the relative contributions of multipartite intracellular signaling pathways to the short-term induction of striatal gene expression by BDNF. To identify genes regulated by BDNF in these GABAergic cells, we first used DNA microarrays to quantify their transcriptomic responses following 3 h of BDNF exposure. The signal transduction pathways underlying

SUBMITTER: Gokce O 

PROVIDER: S-EPMC2669182 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature