P21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae.

ABSTRACT: Each time Saccharomyces cerevisiae cells divide they ensure that both the mother and daughter cell inherit a vacuole by actively transporting a portion of the vacuole into the bud. As the mother cell begins budding, a tubular and vesicular segregation structure forms that is transported into the bud by the myosin V motor Myo2, which is bound to the vacuole-specific myosin receptor, Vac17 (41, 59, 70, 79). Upon arriving in the bud the segregation structure is resolved to found the daughter vacuole. The mechanism that regulates segregation structure resolution in a spatially dependent manner is unknown. In addition to resolving the segregation structure, Vac17 is degraded specifically in the bud to provide directionality to vacuole inheritance. It has been proposed that bud-specific degradat

SUBMITTER: Bartholomew CR 

PROVIDER: S-EPMC2669209 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature