Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice.

ABSTRACT: Breast cancer development is a complex pathobiological process involving sequential genetic alterations in normal epithelial cells that results in uncontrolled growth in a permissive microenvironment. Accordingly, physiologically relevant models of human breast cancer that recapitulate these events are needed to study cancer biology and evaluate therapeutic agents. Here, we report the generation and utilization of the human breast cancer in mouse (HIM) model, which is composed of genetically engineered primary human breast epithelial organoids and activated human breast stromal cells. By using this approach, we have defined key genetic events required to drive the development of human preneoplastic lesions as well as invasive adenocarcinomas that are histologically similar to those in pati

SUBMITTER: Wu M 

PROVIDER: S-EPMC2669443 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature