Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration.

ABSTRACT:

Purpose

Tenomodulin (TNMD) is located in the X-chromosome encoding a putative angiogenesis inhibitor which is expressed in retina. Associations of single nucleotide polymorphisms of TNMD with the prevalence of age-related macular degeneration (AMD) were examined.

Methods

Six markers covering 75% of the common sequence variation in the coding region of TNMD and 10 kb up- and downstream were genotyped in a sample consisting of 89 men and 175 women with exudative AMD, 18 men and 25 women with atrophic AMD, and 55 men and 113 women without AMD. All participants were over 65 years old and did not have diabetes mellitus. Due to the chromosomal locus, the association of genotypes with AMD was assessed genderwise.

Results

Three markers, rs1155974, rs2073163, and rs7890586, we

SUBMITTER: Tolppanen AM 

PROVIDER: S-EPMC2669446 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature