MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells.

ABSTRACT:

Background

The unique features of human embryonic stem (hES) cells make them the best candidate resource for both cell replacement therapy and development research. However, the molecular mechanisms responsible for the simultaneous maintenance of their self-renewal properties and undifferentiated state remain unclear. Non-coding microRNAs (miRNA) which regulate mRNA cleavage and inhibit encoded protein translation exhibit temporal or tissue-specific expression patterns and they play an important role in development timing.

Results

In this study, we analyzed miRNA and gene expression profiles among samples from 3 hES cell lines (H9, I6 and BG01v), differentiated embryoid bodies (EB) derived from H9 cells at different time points, and 5 adult cell types including Human Microva

SUBMITTER: Ren J 

PROVIDER: S-EPMC2669448 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature