Finding evolutionarily conserved cis-regulatory modules with a universal set of motifs.

ABSTRACT:

Background

Finding functional regulatory elements in DNA sequences is a very important problem in computational biology and providing a reliable algorithm for this task would be a major step towards understanding regulatory mechanisms on genome-wide scale. Major obstacles in this respect are that the fact that the amount of non-coding DNA is vast, and that the methods for predicting functional transcription factor binding sites tend to produce results with a high percentage of false positives. This makes the problem of finding regions significantly enriched in binding sites difficult.

Results

We develop a novel method for predicting regulatory regions in DNA sequences, which is designed to exploit the evolutionary conservation of regulatory elements between species without a

SUBMITTER: Wilczynski B 

PROVIDER: S-EPMC2669485 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature