Mood, side-effects and smoking outcomes among persons with and without probable lifetime depression taking varenicline.

ABSTRACT:

Background

Varenicline may be associated with greater mood disturbance and side-effects among smokers with psychiatric history, but empirical evidence is limited. Differential treatment effectiveness by psychiatric history may also exist.

Objective

To compare mood, prevalence and intensity of treatment side-effects, and abstinence among people with a probable history of major depression (DH+) or not (DH-) who took varenicline and received behavioral smoking cessation treatment.

Design

Smokers participated in a randomized behavioral intervention effectiveness trial. Treatment side-effects and outcomes were compared between DH+ and DH- participants (n = 1,117) at 21 [corrected] days and 3 months after the target quit date.

Participants

Smokers recruited from a la

SUBMITTER: McClure JB 

PROVIDER: S-EPMC2669860 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature