Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin.

ABSTRACT:

Background

Genotype-guided initial warfarin dosing may reduce over-anticoagulation and serious bleeding compared to a one-dose-fits-all dosing method.

Objective

The objective of this review was to investigate the safety and efficacy of genotype-guided dosing of warfarin in reducing the occurrence of serious bleeding events and over-anticoagulation.

Data sources

The authors searched PubMed, EMBASE and International Pharmaceutical Abstracts through January 23, 2009, without language restrictions. Selected articles were randomized trials comparing pharmacogenetic dosing of warfarin versus a "standard" dose control algorithm in adult patients taking warfarin for the first time.

Review methods

Two reviewers independently extracted data and assessed study quality usi

SUBMITTER: Kangelaris KN 

PROVIDER: S-EPMC2669873 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature