Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.

ABSTRACT: Unipolar major depressive disorder (MDD) is a prevalent, disabling condition with multiple genetic and environmental factors impacting disease risk. The diagnosis of MDD relies on a cumulative measure derived from multiple trait dimensions and alone is limited in elucidating MDD genetic determinants. We and others have proposed that MDD may be better dissected using paradigms that assess how specific genes associate with component features of MDD. This within-disease design requires both a well-phenotyped cohort and a robust statistical approach that retains power with multiple tests of genetic association. In the present study, common polymorphic variants of genes related to central monoaminergic and cholinergic pathways that previous studies align with functional change in vitro or depre

SUBMITTER: Hahn MK 

PROVIDER: S-EPMC2670227 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature