Evolution of the class C GPCR Venus flytrap modules involved positive selected functional divergence.

ABSTRACT:

Background

Class C G protein-coupled receptors (GPCRs) represent a distinct group of the GPCR family, which structurally possess a characteristically distinct extracellular domain inclusive of the Venus flytrap module (VFTM). The VFTMs of the class C GPCRs is responsible for ligand recognition and binding, and share sequence similarity with bacterial periplasmic amino acid binding proteins (PBPs). An extensive phylogenetic investigation of the VFTMs was conducted by analyzing for functional divergence and testing for positive selection for five typical groups of the class C GPCRs. The altered selective constraints were determined to identify the sites that had undergone functional divergence via positive selection. In order to structurally demonstrate the pattern changes during the

SUBMITTER: Cao J 

PROVIDER: S-EPMC2670285 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature