The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes.

ABSTRACT:

Background

Cryptococcus neoformans is an encapsulated yeast that is a facultative intracellular pathogen. The interaction between macrophages and C. neoformans is critical for extrapulmonary dissemination of this pathogenic yeast. C. neoformans can either lyse macrophages or escape from within them through a process known as phagosomal extrusion. However, most studies of intracellular pathogenesis have been made with mouse cells and their relevance to human infection is uncertain. In this study we extended studies of C. neoformans-macrophage cellular interaction/s to human peripheral blood monocytes.

Results

This study demonstrated that C. neoformans can shed polysaccharide within human monocytes, spread from cell to cell, and be extruded from them. Furthermore, human monocy

SUBMITTER: Alvarez M 

PROVIDER: S-EPMC2670303 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature