Heterogeneous output pathways link the anterior pretectal nucleus with the zona incerta and the thalamus in rat.

ABSTRACT: The anterior pretectal nucleus (APT) and the zona incerta (ZI) are diencephalic nuclei that exert a strong inhibitory influence selectively in higher order thalamic relays. The APT is also known to project to the ZI as well as the thalamus, but anatomical details of the APT-ZI projection have not been described. In the present study, the efferent pathways of the APT were examined in the APT-ZI-thalamus network by using anterograde and retrograde tracing in combination with pre- and postembedding immunocytochemical stainings and in situ hybridization. The vast majority of APT fibers selectively innervated the parvalbumin-positive, ventral part of the ZI, which contains ZI neurons with axons projecting to higher order thalamic nuclei. The APT-ZI pathway consisted of both gamma-aminobutyric a

SUBMITTER: Giber K 

PROVIDER: S-EPMC2670449 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature