Modeling Adult Gliomas Using RCAS/t-va Technology.

ABSTRACT: Malignant gliomas remain the most devastating childhood and adult tumors of the central nervous system. Although adult and pediatric gliomas are histologically indistinguishable, they differ in location, behavior, and molecular characteristics. This implies that the molecular pathways and pathophysiology of malignant gliomagenesis in these two populations are distinct. Such differences between adult and pediatric gliomas may predict different therapeutic responses. Therefore, accurate genetically engineered models of adult and pediatric gliomas may help understand the biology of these tumors and evaluate therapeutic agents in preclinical studies. It has been proposed that gliomas arise from the subventricular zone in mice during development. Here, we demonstrate that, in adult mice, glioma

SUBMITTER: Hambardzumyan D 

PROVIDER: S-EPMC2670576 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature