Persistence of virological benefits following directly administered antiretroviral therapy among drug users: results from a randomized controlled trial.

ABSTRACT:

Background

Although directly administered antiretroviral therapy (DAART) has demonstrated impressive biological benefits compared with self-administered therapy (SAT) among drug users, the persistence of DAART after transition to SAT has not been examined.

Methods

We conducted a community-based, prospective, randomized controlled trial of 6 months of DAART compared with SAT. The primary outcome was the proportion of subjects who achieved virological success at 6 months postintervention, defined as either a 1.0 log10 reduction from baseline or HIV-1 RNA <400 copies per milliliter. Secondary outcomes included the change from baseline in HIV-1 RNA and CD4 lymphocyte count.

Results

Of the 53 subjects in the SAT arm and 88 subjects in the DAART arm, 52 and 82, respectively

SUBMITTER: Maru DS 

PROVIDER: S-EPMC2670996 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature