Comparison of three protocols for tight glycemic control in cardiac surgery patients.

ABSTRACT:

Objective

We performed a randomized trial to compare three insulin-titration protocols for tight glycemic control (TGC) in a surgical intensive care unit: an absolute glucose (Matias) protocol, a relative glucose change (Bath) protocol, and an enhanced model predictive control (eMPC) algorithm.

Research design and methods

A total of 120 consecutive patients after cardiac surgery were randomly assigned to the three protocols with a target glycemia range from 4.4 to 6.1 mmol/l. Intravenous insulin was administered continuously or in combination with insulin boluses (Matias protocol). Blood glucose was measured in 1- to 4-h intervals as requested by the protocols.

Results

The eMPC algorithm gave the best performance as assessed by time to target (8.8 +/- 2.2 vs. 10.9 +/-

SUBMITTER: Blaha J 

PROVIDER: S-EPMC2671097 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature