The effect of ABO blood incompatibility on corneal transplant failure in conditions with low-risk of graft rejection.

ABSTRACT:

Purpose

To determine whether corneal graft survival over a 5-year follow-up period was affected by ABO blood type compatibility in participants in the Cornea Donor Study undergoing corneal transplantation principally for Fuchs dystrophy or pseudophakic corneal edema, conditions at low-risk for graft rejection.

Design

Multi-center prospective, double-masked, clinical trial.

Methods

ABO blood group compatibility was determined for 1,002 donors and recipients. During a 5-year follow-up period, episodes of graft rejection were documented, and graft failures were classified as to whether or not they were attributable to immunologic rejection. Endothelial cell density was determined by a central reading center for a subset of subjects.

Results

ABO donor-recipient inc

SUBMITTER: Dunn SP 

PROVIDER: S-EPMC2671194 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature