Neurodevelopment genes in lampreys reveal trends for forebrain evolution in craniates.

ABSTRACT: The forebrain is the brain region which has undergone the most dramatic changes through vertebrate evolution. Analyses conducted in lampreys are essential to gain insight into the broad ancestral characteristics of the forebrain at the dawn of vertebrates, and to understand the molecular basis for the diversifications that have taken place in cyclostomes and gnathostomes following their splitting. Here, we report the embryonic expression patterns of 43 lamprey genes, coding for transcription factors or signaling molecules known to be involved in cell proliferation, stemcellness, neurogenesis, patterning and regionalization in the developing forebrain. Systematic expression patterns comparisons with model organisms highlight conservations likely to reflect shared features present in the ver

SUBMITTER: Guerin A 

PROVIDER: S-EPMC2671401 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature