Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis.

ABSTRACT:

Background

Analysis of the pathogen interactome is a powerful approach for dissecting potential signal transduction and virulence pathways. It also offers opportunities for exploring new drug targets.

Results

In this study, a protein-protein interaction (PPI) network of Mycobacterium tuberculosis H37Rv was constructed using a homogenous protein mapping method, which has shown molecular chaperones, ribosomal proteins and ABC transporters to be highly interconnected proteins. A further analysis of this network unraveled the function of hypothetical proteins as well as a potential signaling pathway. A hypothetical protein, Rv2752c, which was linked to a metal cation-transporting ATPase, was characterized as a metal-beta-lactamase, through domain analysis in combination with an

SUBMITTER: Cui T 

PROVIDER: S-EPMC2671525 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature