Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting.

ABSTRACT:

Background

Angiogenesis, the growth of capillaries from preexisting blood vessels, has been extensively studied experimentally over the past thirty years. Molecular insights from these studies have lead to therapies for cancer, macular degeneration and ischemia. In parallel, mathematical models of angiogenesis have helped characterize a broader view of capillary network formation and have suggested new directions for experimental pursuit. We developed a computational model that bridges the gap between these two perspectives, and addresses a remaining question in angiogenic sprouting: how do the processes of endothelial cell elongation, migration and proliferation contribute to vessel formation?

Results

We present a multiscale systems model that closely simulates the mechanis

SUBMITTER: Qutub AA 

PROVIDER: S-EPMC2672076 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature