Male-pattern baldness susceptibility locus at 20p11.

ABSTRACT: We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).

SUBMITTER: Richards JB 

PROVIDER: S-EPMC2672151 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature