PARL Leu262Val is not associated with fasting insulin levels in UK populations.

ABSTRACT:

Aims/hypothesis

PARL, the gene encoding presenilins-associated rhomboid-like protein, maps to chromosome 3q27 within a quantitative trait locus that influences components of the metabolic syndrome. Recently, an amino acid substitution (Leu262Val, rs3732581) in PARL was associated with fasting plasma insulin levels in a US white population (N=1031). This variant was also found to modify the positive association between age and fasting insulin. The aim of this study was to test whether these findings could be replicated in two UK population-based cohorts.

Methods

Participants from the Medical Research Council Ely and Hertfordshire cohort studies were genotyped for this variant using a SNaPshot primer extension assay and Taqman assay respectively. Full phenotypic and genotypic

SUBMITTER: Fawcett KA 

PROVIDER: S-EPMC2672784 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature