Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease.

ABSTRACT:

Objective

Human bocavirus (HBoV) is a recently discovered parvovirus associated with acute respiratory tract infections in children. The objective of the present study was to determine the frequency and clinical relevance of HBoV infection in adult patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD).

Methods

We retrospectively tested 212 COPD patients, 141 (66.5%) with AE-COPD and 71 (33.5%) with stable disease, of whom nasal lavage and induced sputum had been obtained for the presence of HBoV deoxyribonucleic acid (DNA). The specificity of positive polymerase chain reaction results was confirmed by sequencing.

Results

Two hundred two of 212 patients for whom PCR results were available both for nasal lavage and induced sputum samples we

SUBMITTER: Ringshausen FC 

PROVIDER: S-EPMC2672801 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature