The activation of M1 muscarinic receptor signaling induces neuronal differentiation in pyramidal hippocampal neurons.

ABSTRACT: Muscarinic receptors have been proposed to play an important role during brain development by regulating cell survival, proliferation, and differentiation. This study investigated the effect of muscarinic receptor activation on prenatal rat hippocampal pyramidal neuron differentiation and the signal transduction pathways involved in this effect. The cholinergic agonist carbachol, after 24 h in vitro, increased the length of the axon, without affecting the length of minor neurites. Carbachol-induced axonal growth was also observed in pyramidal neurons from the neocortex but not in granule neurons from the cerebellum. The effect of carbachol was mediated by the M(1) subtype of muscarinic receptors. The Ca(2+) chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid-acetoxymethyl est

SUBMITTER: VanDeMark KL 

PROVIDER: S-EPMC2672861 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature