Disability in optic neuritis correlates with diffusion tensor-derived directional diffusivities.

ABSTRACT:

Objective

To determine the potential of directional diffusivities from diffusion tensor imaging (DTI) to predict clinical outcome of optic neuritis (ON), and correlate with vision, optical coherence tomography (OCT), and visual evoked potentials (VEP).

Methods

Twelve cases of acute and isolated ON were imaged within 30 days of onset and followed prospectively. Twenty-eight subjects with a remote clinical history of ON were studied cross-sectionally. Twelve healthy controls were imaged for comparison. DTI data were acquired at 3T with a surface coil and 1.3 x 1.3 x 1.3 mm(3) isotropic voxels.

Results

Normal DTI parameters (mean +/- SD, microm(2)/ms) were axial diffusivity = 1.66 +/- 0.18, radial diffusivity = 0.81 +/- 0.26, apparent diffusion coefficient (ADC) = 1.09 +

SUBMITTER: Naismith RT 

PROVIDER: S-EPMC2672917 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature