IgCAMs redundantly control axon navigation in Caenorhabditis elegans.

ABSTRACT:

Background

Cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) form one of the largest and most diverse families of adhesion molecules and receptors in the nervous system. Many members of this family mediate contact and communication among neurons during development. The Caenorhabditis elegans genome contains a comparatively small number of IgCAMs, most of which are evolutionarily conserved and found across all animal phyla. Only some of these have been functionally characterized so far.

Results

We systematically analyzed previously uncharacterized IgCAMs in C. elegans. Green fluorescent protein reporter constructs of 12 IgCAMs revealed that expression generally is not confined to a single tissue and that all tissues express at least one of the IgCAMs. Most Ig

SUBMITTER: Schwarz V 

PROVIDER: S-EPMC2672934 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature