Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina.

ABSTRACT:

Purpose

The size of neuronal populations is modulated by gene variants that influence cell production and survival, in turn influencing neuronal connectivity, function, and disease risk. The size of the dopaminergic amacrine (DA) cell population is a highly heritable trait exhibiting sixfold variation among inbred strains of mice and is used here to identify genes that modulate the number of DA cells.

Methods

The entire population was counted in retinal wholemounts from 37 genetically defined lines of mice, including six standard inbred strains, 25 recombinant inbred strains (AXB/BXA), reciprocal F1 hybrids, a chromosome (Chr) 7 consomic line, and three additional genetically modified lines.

Results

Much of this variation was mapped to a broad locus on Chr 7 (Dopamine

SUBMITTER: Whitney IE 

PROVIDER: S-EPMC2672967 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature